Research and Publications
Below are key publications by The NCDC scientists. Click on the link following the article title to open and view in a new window.
Reviews and Hypotheses
Shi P, Raizada MK, Sumners C. Brain Cytokines as Neuromodulators in Cardiovascular Control. Clin Exp Pharmacol Physiol (Jun 29 2009; Epub ahead of print). (click for pdf)
Fink GD. Sympathetic activity, vascular capacitance and long-term regulation of arterial pressure. Hypertension 53: 307-312, 2009. (click for pdf)
Osborn JW, Averina VA, Fink GD. Current computational models do not reveal the importance of the nervous system in long-term control of arterial pressure. Exp Physiol 94(4): 381-397, 2009. (click for pdf)
Abrams JM, Osborn JW. A role for benzamil sensitive proteins of the central nervous system in the pathogenesis of salt-dependent hypertension. Clin Exp Phys Pharm 35: 687-694, 2008. (click for pdf)
Osborn JW, Fink GD, Sved AF, Toney GM, Raizada MK. Circulating angiotensin II and dietary salt: converging signals for neurogenic hypertension. Current Hypertension Reports 9: 228-235, 2007. (click for pdf)
Osborn, JW. Hypothesis: set-points and long-term control of arterial pressure. A theoretical argument for a long-term arterial pressure control system in the brain rather than the kidney. Clin Exp Pharmacol Physiol 32(5-6): 384-93, 2005. (click for pdf)
Integrative aspects of experimental AngII-salt hypertension
King A, Novatny M, Swain GM, Fink GD. Whole body norepinephrine kinetics in ANG II-salt hypertension in the rat Am. J. Physiol. 294: R1262-R1267, 2008. (click for pdf)
King A, Osborn JW, Fink GD. Splanchnic circulation is a critical neural target in angiotensin II-salt hypertension in rats. Hypertension 50(3); 547-556, 2007. (click for pdf)
King AJ and Fink GD. Chronic low-dose angiotensin II infusion increases venomotor tone by neurogenic mechanisms. Hypertension 48: 927-933, 2006. (click for pdf)
Fine DM, Ariza-Nieto P, Osborn JW. Does whole body autoregulation mediate the hemodynamic responses to increased dietary salt in rats with clamped ANG II? Am J Physiol 285: H2670-H2678, 2003. (click for pdf)
Osborn JW, Ariza-Nieto P, Collister JP, Soucherary S, Zimmerman B, Katz S. Responsiveness vs. basal activity of plasma AngII as a determinant of arterial pressure salt sensitivity. Am J Physiol 285: H2142-H2149, 2003. (click for pdf)
Central pathways integrating AngII and osmotic inputs and the control of sympathetic nerve activity
Shan Z, Cuadra AE, Sumners C, Raizada MK. Characterization of a functional (pro)renin receptor in rat brain neurons. Exp Physiol 93(5): 701-8, 2008. (click for pdf)
Shi P, Stocker SD, Toney GM. Organum vasculosum laminae terminalis (OVLT) contributes to increased sympathetic nerve activity induced by central hyperosmolality. Am J Physiol 293: R2279-R2289, 2007. (click for pdf)
Yamazato M, Yamazato Y, Sun C, Diez-Freire C, Raizada MK. Overexpression of angiotensin-converting enzyme 2 in the rostral ventrolateral medulla causes long-term decrease in blood pressure in the spontaneously hypertensive rats. Hypertension 9(4): 926-31, 2007. (click for pdf)
Card JP, Sved JC, Craig B, Raizada M, Vazquez J, Sved AF. Efferent projections of rat rostroventrolateral medulla C1 catecholamine neurons: Implications for the central control of cardiovascular regulation. J Comp Neurol 499: 840-859, 2006. (click for pdf)
Stocker SD and Toney GM. Median preoptic neurons projecting to the hypothalamic PVN respond to osmotic, circulating ANG II, and baroreceptor input. J Physiol (London) 568(Pt 2): 599-615, 2005. (click for pdf)
Cano G, Card JP, Sved AF. Dual viral transneuronal tracing of central autonomic circuits involved in the innervation of the two kidneys in rat. J Comp Neurol 471: 462-481, 2004. (click for pdf)
Chen QH and Toney GM. Identification and Characterization of Two Functionally Distinct Groups of Spinal Cord-Projecting PVN Neurons with Sympathetic-Related Activity. Neuroscience 118(3): 797-807, 2003. (click for pdf)
Ito S, Hiratsuka M, Komatsu K, Tsukamoto K, Kanmatsuse K, Sved AF. Ventrolateral medulla AT1 receptors support pressure in Dahl salt-sensitive rats. Hypertension 41: 744-750, 2003. (click for pdf)
Regulation of sympathetic activity in humans
Charkoudian N, Eisenach JH, Joyner MJ, Roberts SK, Wick DE. Interactions of plasma osmolality with arterial and central venous pressures in control of sympathetic activity and heart rate in humans. Am J Physiol 289 (6): H2456-H2460, 2005. (click for pdf)
Charkoudian N, Martin EA, Dinenno FA, Eisenach JH, Dietz NM, Joyner MJ. Influence of increased central venous pressure on baroreflex control of sympathetic activity in humans. Am J Physiol 287: H1658-H1662, 2004. (click for pdf)
Charkoudian N, Halliwill JR, Morgan BJ, Eisenach JH, Joyner MJ. Influences of hydration on post-exercise cardiovascular control in humans. J Physiol (London) 552: 635-644, 2003. (click for pdf)
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